产品货号：
Z29714
中文名称：
XEDAR/EDA2R抗体
英文名称：
Anti-XEDAR/EDA2R Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-XEDAR/EDA2R Antibody |
| 指标别名 | XEDAR;EDAA2R;EDA-A2R;TNFRSF27;XEDAR;UNQ2448/PRO5727/PRO34080;Tumor necrosis factor receptor superfamily member 27;X-linked ectodysplasin-A2 receptor;EDA-A2 receptor |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | EDA2R |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | XEDAR antibody was raised against recombinant human XEDAR. |
| 计算分子量 | 33kDa |
| 成分 | XEDAR Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | XEDAR Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2).Two predominantly expressed isoforms,XEDAR-s and XEDAR-L,differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain.Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-百B and JNK pathways.Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD,caspase-8 and caspase-10,leading to the activation caspase-8 and caspase-3,and finally apoptosis.The EDA-A2-induced apoptosis is dependent on caspase-9 activation,as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment. |
| Uniprot ID | Q9HAV5 |
| 基因名全称 | Ectodysplasin A2 receptor |
| 蛋白名全称 | Ectodysplasin A2 receptor |
| 推荐稀释比 | XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.Antibody validated:Western Blot in human samples and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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